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Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.

Identifieur interne : 000130 ( France/Analysis ); précédent : 000129; suivant : 000131

Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.

Auteurs : Christine Durier [France] ; Corinne Desaint [France] ; Frédéric Lucht [France] ; Pierre-Marie Girard ; Yves Lévy [France] ; Thierry May [France] ; Christian Michelet [France] ; Agathe Rami ; François Roman ; Jean-François Delfraissy [France] ; Jean-Pierre Aboulker [France] ; Odile Launay [France]

Source :

RBID : Hal:hal-00875148

Abstract

OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.


Url:
DOI: 10.1097/QAD.0b013e328359f27a


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Hal:hal-00875148

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<name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-François" last="Delfraissy">Jean-François Delfraissy</name>
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<author>
<name sortKey="Launay, Odile" sort="Launay, Odile" uniqKey="Launay O" first="Odile" last="Launay">Odile Launay</name>
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<addrLine>Hopital Cochin PARIS V 27, Rue du Faubourg Saint-Jacques 75679 PARIS CEDEX 14</addrLine>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
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<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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<ref type="url">http://www.inserm.fr</ref>
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</org>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1097/QAD.0b013e328359f27a</idno>
<series>
<title level="j">AIDS</title>
<idno type="ISSN">0269-9370</idno>
<imprint>
<date type="datePub">2013-01-02</date>
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<div type="abstract" xml:lang="en">
<p>OBJECTIVE: In immunocompromised patients, alternative schedules more immunogenic than the standard influenza vaccine regimen are necessary to enhance and prolong vaccine efficacy. We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response. DESIGN AND METHODS: In a prospective, multicenter, randomized, patient-blinded trial, two doses of AS03A-adjuvanted H1N1v vaccine containing 3.75 μg haemagglutinin (n = 155; group A) or nonadjuvanted H1N1v vaccine containing 15 μg haemagglutinin (n = 151; group B), were administered 21 days apart. Haemagglutination inhibition and neutralizing antibodies were assessed 6 and 12 months after vaccination. RESULTS: In group A and B, the seroprotection rates were 83.7 and 59.4% at month 6, and 70.4 and 49.3 at month 12, respectively. In a multivariate analysis, persistence of seroprotection 12 months after vaccination was negatively associated with current smoking (odds ratio = 0.6, P = 0.03) and positively related with the AS03A-adjuvanted H1N1v vaccine (odds ratio = 2.7, P = 0.0002). CONCLUSION: In HIV-1-infected adults, two doses of adjuvanted influenza vaccine induce long-term persistence of immune response up to 1 year after vaccination.</p>
</div>
</front>
</TEI>
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<list>
<country>
<li>France</li>
</country>
<region>
<li>Pays de la Loire</li>
<li>Région Bretagne</li>
</region>
<settlement>
<li>Angers</li>
<li>Rennes</li>
</settlement>
<orgName>
<li>Université d'Angers</li>
<li>Université de Rennes 1</li>
<li>Université européenne de Bretagne</li>
</orgName>
</list>
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<name sortKey="Girard, Pierre Marie" sort="Girard, Pierre Marie" uniqKey="Girard P" first="Pierre-Marie" last="Girard">Pierre-Marie Girard</name>
<name sortKey="Rami, Agathe" sort="Rami, Agathe" uniqKey="Rami A" first="Agathe" last="Rami">Agathe Rami</name>
<name sortKey="Roman, Francois" sort="Roman, Francois" uniqKey="Roman F" first="François" last="Roman">François Roman</name>
</noCountry>
<country name="France">
<noRegion>
<name sortKey="Durier, Christine" sort="Durier, Christine" uniqKey="Durier C" first="Christine" last="Durier">Christine Durier</name>
</noRegion>
<name sortKey="Aboulker, Jean Pierre" sort="Aboulker, Jean Pierre" uniqKey="Aboulker J" first="Jean-Pierre" last="Aboulker">Jean-Pierre Aboulker</name>
<name sortKey="Delfraissy, Jean Francois" sort="Delfraissy, Jean Francois" uniqKey="Delfraissy J" first="Jean-François" last="Delfraissy">Jean-François Delfraissy</name>
<name sortKey="Desaint, Corinne" sort="Desaint, Corinne" uniqKey="Desaint C" first="Corinne" last="Desaint">Corinne Desaint</name>
<name sortKey="Launay, Odile" sort="Launay, Odile" uniqKey="Launay O" first="Odile" last="Launay">Odile Launay</name>
<name sortKey="Levy, Yves" sort="Levy, Yves" uniqKey="Levy Y" first="Yves" last="Lévy">Yves Lévy</name>
<name sortKey="Lucht, Frederic" sort="Lucht, Frederic" uniqKey="Lucht F" first="Frédéric" last="Lucht">Frédéric Lucht</name>
<name sortKey="May, Thierry" sort="May, Thierry" uniqKey="May T" first="Thierry" last="May">Thierry May</name>
<name sortKey="Michelet, Christian" sort="Michelet, Christian" uniqKey="Michelet C" first="Christian" last="Michelet">Christian Michelet</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Sante
   |area=    H2N2V1
   |flux=    France
   |étape=   Analysis
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   |texte=   Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults.
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